These two teams have already met once this season with the Patriots absolutely exploding in the second half with a whopping 45 points as they marched their way to a 52-28 victory in Buffalo.
With the game being in Foxboro, let's take a look at my bold predictions for Week 10.
1. Rob Gronkowski will score two touchdowns
With Aaron Hernandez being inactive this week as he'll miss his second consecutive game due to an ankle injury, fellow tight end Rob Gronkowski will have a big deal.
When these two teams met back in late September, Gronk was able to snag five passes for 104 yards and one score, in front of his home-town crowd.
Gronk will continue his hot streak Sunday afternoon, as he'll record two touchdown receptions for the third straight game.
C.J. Spiller and Fred Jackson are arguably the NFL's most dynamic and most effective running back tandem in the NFL, but good news for the Pats: New England has the seventh best run defense.
Spiller and Jackson both weren't 100 percent back in the team's first meeting, but they won't even be a factor this weekend, as New England's run defense will shut them down and force quarterback Ryan Fitzpatrick to beat them.
3. Ryan Fitzpatrick will be picked off four times
Is this a re-run? I think so.
Ryan Fitzpatrick might have thrown four touchdowns against the Pats back in September, but he was picked off four times—and I see that happening once again.
Fitzpatrick has been an interception machine thus far in 2012 and he'll continue that trend as he'll be picked off four times and will just toss two scores this week.
4. Tom Brady will throw four-plus touchdowns
As of right now, there might be one or two quarterbacks that are playing as good as Tom Brady is right now.
Brady is coming off of a four touchdown performance against the St. Louis Rams back in Week 8 in London, and I see him absolutely shredding Buffalo's 24th ranked pass defense.
Back in Week 4 against the Bills, Brady threw for three scores, 340 yards and posted a 120.1 quarterback rating as well as punching in a touchdown on the ground.
Out of every team in the NFL, it certainly seems like Brady is at his best against the Buffalo Bills.
5. Final prediction: New England: 45 Buffalo: 13
I hate to say this but I really don't think the Bills have any shot at leaving New England with a victory.
The Patriots have had two weeks to prepare for the struggling Bills and Brady is simply going to demolish Buffalo's secondary.
If you have any Patriots that are on your fantasy team, I suggest that you start them—they'll all be racking up the points Sunday at Gillette.