Mayo's right knee appeared to twist and buckle on a non-contact play. He was carted off the field, and from the reaction of the Patriots players, it looked serious.
Mayo was declared out for the remainder of the game. We'll provide updates as soon as we hear them, and will obviously hope this isn't as serious as it looks.
It would be a tough break for Mayo, who went down for the 2013 season with a torn pectoral muscle in week six.
Left guard Dan Connolly also departed to the locker room with the training staff for an apparent head injury. He is questionable to return to the game. In his place, the Patriots inserted Jordan Devey at left guard. Second year pro Josh Kline started the game at right guard.