RB Dion Lewis: The Colts defensive line has improved in the offseason with the additions of Kendall Langford, Henry Anderson, and David Parry. That probably means less snaps for LeGarrette Blount and more for Neon Dion. If there is one glaring weakness in the Colts defense, it's their inside linebackers. Not only do they struggle to get off blocks, they also struggle against RBs and TEs in isolated man coverage. The Colts are not a very good tackling team and putting in the most difficult RB to tackle in the NFL is a perfect storm for Lewis to post up a big game. Lewis will likely push 150 combined yards in the game.
LB Jamie Collins: With Dont'a Hightower's injury in the Cowboys game, a lot responsibility has likely been placed on Collins' shoulders. For the on-field stuff, he doesn't need to do anything different. With his ability to affect the passing game at multiple levels, he should give Luck/Hasselbeck fits on blitzes and in coverage against the outlet receivers and TEs in the middle of the field. Collins has forced a fumble in 3 straight games, which is a bad match for the turnover-prone Colts.