4:05 PM EST
Browns at Chargers: San Diego is the 6.5 point favorite, but are coming off back-to-back losses to the Bengals and the Vikings after opening the year with a win against the Lions. The Browns are 1-2 with losses to the Jets and Raiders, and a win against the Titans. I think this is closer than expected, but the Chargers still win 21-17.
4:25 PM EST
Packers at 49ers: Green Bay will win, but the question is by how much? How are the Packers only 7.0 point favorites, and the line has tightened after opening as 9.5 point favorites. Is Green Bay going to rest Aaron Rodgers after the first quarter? Packers win 35-10.
Rams at Cardinals: The Rams have a great defensive line and they always challenge the best teams in the NFC West. Arizona is the 7.0 point favorite, but I think St. Louis covers at the end, with the Cardinals winning 24-20.
Vikings at Broncos: Denver is the 7.0 point favorite. Can the offense find its groove? The Broncos win another ugly one 23-17.
8:30 PM EST
Cowboys at Saints: Drew Brees might play for the 3.0 point favorite Saints. If so, the Saints win in a shoot out, 35-31.