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The New York Giants rank 26th against the pass and 7th against the run, per Football Outsiders' ranking. It doesn't take a rocket surgeon to figure out how the Patriots are going to attack this defense.
Tom Brady is primed to have a major day, especially with the Giants secondary in shambles. The Giants have one great corner in Dominique Rodgers-Cromartie and they move him around the formation. He typically handles outside players, so look for him to match-up against Brandon LaFell. The rest of the secondary isn't great and it allows the Patriots to pick on the other defensive backs.
That means that Julian Edelman is set up to have a great day. Edelman has been the quiet model of consistency this year, but his volume has been down in recent weeks due to drops and fumbles and a need to run out the clock against Washington so no one else would get hurt. The wide receiver is set up to have a great match-up and he should get back on track with 8+ targets on the day.
Tight end Rob Gronkowski is another must-play, as always. Football Outsiders ranks the Giants 25th in defending tight ends and they have allowed an average of 7 receptions for 94 yards and 0.5 touchdowns to the likes of Jason Witten, Jacob Tamme, Jordan Reed, Charles Clay, and Ben Watson. Look for Gronkowski to break all the averages.
As for running backs, I would expect this to be a James White game, with a healthy mix of LeGarrette Blount, but with neither player seeing a sufficient number of touches to make them viable in fantasy. If you had to choose one, I would expect Blount to snag a goal line touchdown, while White is a threat to pick up a handful of receptions and yards in a PPR league.
The only Giants player I'd feel confident promoting is Odell Beckham Jr., who I believe will draw Malcolm Butler in coverage. I don't think Eli Manning offers much more than what you might find on the waiver wire, and the Giants run game is fairly nonexistent.