The New England Patriots are really feeling their early-season bye week as the injury report is loaded with key players.
Linebacker Jamie Collins (illness), cornerback Justin Coleman (wrist), and wide receiver Julian Edelman (foot) have been declared OUT. Edelman is likely out until the final weeks of the season, while Collins and Coleman look to return after this week.
Collins has been targeting a return against the Broncos as his illness forced him to lose a lot of weight and strength. Linebackers Jerod Mayo and Jonathan Freeny will be the top options to step into the starting role. Coleman is a big loss since Rashaan Melvin is the only back-up cornerback on the roster. It's possible for the Patriots to use one of their safeties instead of Melvin.
Linemen Marcus Cannon (toe), Sebastian Vollmer (concussion), and Tre Jackson (knee) are listed as questionable, but it's possible that the first two step right into the starting line-up, while Jackson gets another week of rest due to the great depth on the interior. Wide receiver Keshawn Martin (hamstring) is also questionable, which sets up rookie Chris Harper for a possibly high-impact day.
Guard Shaq Mason (knee) is probable and should start at left guard, while defensive linemen Alan Branch (elbow), Chandler Jones (abdominal), and Jabaal Sheard (ankle) are all probable, too.
The Bills will be without defensive tackle Kyle Williams (knee), greatly weakening their interior against the run. Guard Richie Incognito is questionable (shoulder), but should play, while tackle Cyrus Kouandijo (knee) is listed as probable.