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Quarterback Tom Brady is a must play in every type of league as the Eagles have allowed a ridiculous 5 touchdown passes in each of their past two games to the Buccaneers and the Lions. Eagles quarterback Sam Bradford is still working through a shoulder injury, so stay away from any receiver in the Philadelphia offense.
On the other side of the field, receiver Danny Amendola looks to return and he's primed for a ridiculously fantastic day against a defense that ranks dead last in the NFL at defending wide receivers. Brandon LaFell is also worth a look because he's going to get his targets one way or another.
Tight end Scott Chandler has elevated into must play levels due to the Patriots reliance on the position, and you can be certain that Tom Brady is going to take advantage of this game to try and develop a rapport with the former Buffalo Bill. The Patriots rank 4th in the league at defending against tight ends, so stay away from Eagles tight end Zach Ertz.
Eagles running back DeMarco Murray is going to see plenty of opportunities as fellow back Ryan Mathews recovers from a concussion. Add in the questionable state of the Eagles quarterbacks and regardless of the Patriots top tier run defense, Murray is going to get 20+ touches. Patriots running back LeGarrette Blount is primed to have a big game, especially if the Patriots get into garbage time, but if he disappears this week, you can probably just cut him from your rosters.