The New England Patriots are heavy favorites over the Buffalo Bills according to Las Vegas oddsmakers. Various books have the Patriots ranging from 8.5-to-10.5-point favorites, with some dropping to 7.5-points after the open. The over/under opened at 49.0, too.
These figures project to an average 29-20 victory for New England.
The Patriots have covered the spread in their past five games, which could point to the odds being set a little higher than reality. Still, the Patriots have been playing at a high level, while the Bills have only covered in two of their past seven games.