The Patriots will be down their top two right tackles as Marcus Cannon and LaAdrian Waddle are not playing; Waddle was a game day decision but was not cleared by the trainers ahead of the game. DE Trey Flowers, LB Trevor Reilly, and WR Chris Hogan were all known to be out.
Matthew Slater was another game day inactive and now the Patriots will be without their top two special teamers as Nate Ebner is on the injured reserve.
Mike Gillislee is a healthy scratch, yet again, opening the door for Dion Lewis and Rex Burkhead to continue to produce. Both Gillislee and Hogan are former members of the Buffalo Bills, so fellow former-Bill Stephon Gilmore will have to show up in strong fashion.
This report also means that David Andrews should be back in the line-up at center and Eric Rowe will be active. Kyle Van Noy should play, too.
The Bills will also be short-handed. Cordy Glenn and John Miller are two starting offensive linemen, while Kelvin Benjamin, Nick O’Leary, and Mike Tolbert are all in the top two of their respective skill position.
Conor McDermott was the Patriots sixth round pick in this latest NFL Draft.