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NFL Week 15 odds: Top-seeded Patriots listed as road underdogs against the Colts

Related: Patriots are among the winners of Week 14 without even playing

NFL: New England Patriots at Buffalo Bills Rich Barnes-USA TODAY Sports

The New England Patriots won seven straight games heading into their Week 14 bye, the longest such streak in the NFL. Now at 9-4, they are the top playoff seed in the AFC as well as the leaders of their division. They are one of the hottest teams in football, leading the league with a +150 point differential.

And yet, the oddsmakers do not see them beat the 7-6 Indianapolis Colts on Saturday. According to numbers provided DraftKings Sportsbook, the Patriots are entering the primetime matchup in Indianapolis as 2-point underdogs. The over/under has been set at 46.

A loss in Indianapolis would likely drop New England down the AFC standings, and open the door for 7-6 Buffalo to make up some ground in the AFC East. Likewise, a win would help the Patriots stay atop and give them considerable momentum for their final three-game stretch of the regular season.

NFL Week 15 spreads

Kansas City Chiefs at Los Angeles Chargers

Las Vegas Raiders at Cleveland Browns

Carolina Panthers at Buffalo Bills

Arizona Cardinals at Detroit Lions

Houston Texans at Jacksonville Jaguars

New York Jets at Miami Dolphins

Dallas Cowboys at New York Giants

Washington Football Team at Philadelphia Eagles

Tennessee Titans at Pittsburgh Steelers

Cincinnati Bengals at Denver Broncos

Atlanta Falcons at San Francisco 49ers

Green Bay Packers at Baltimore Ravens

Seattle Seahawks at Los Angeles Rams

New Orleans Saints at Tampa Bay Buccaneers

Minnesota Vikings at Chicago Bears