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NFL Week 16 odds: Patriots open as 2.5-point favorites over the Bills

Related: NFL playoff picture: Patriots’ weekend a disappointment, but at least they received some help on Sunday

New England Patriots v Buffalo Bills Photo by Bryan M. Bennett/Getty Images

So it has come to this. The New England Patriots’ quest to retake the AFC East title will either live or die on Sunday: the Buffalo Bills will visit Gillette Stadium in a massive game for both teams.

A Patriots win would help them stay atop the division and go up two games plus the head-to-head tiebreaker. While New England would mathematically still be able to lose the AFC East crown — but not its spot in the playoff tournament — such a development would be highly unlikely.

A Bills win, on the other hand, would help them tie the Patriots at 9-6 but give them the advantage thanks to a better division record.

According to the oddsmakers, the first scenario is more likely: according to DraftKings Sportsbook, the Patriots enter Week 16 as 2.5-point favorites to win the game. Given that New England already won the first matchup between the two clubs, and still owns a better overall record (9-5 vs. 8-6) this does not come as a surprise.

Still, the numbers show that a close matchup is expected. That is especially true given that home field advantage is usually worth three points.

NFL Week 15 spreads

San Francisco 49ers at Tennessee Titans

Cleveland Browns at Green Bay Packers

Indianapolis Colts at Arizona Cardinals

New York Giants at Philadelphia Eagles

Los Angeles Rams at Minnesota Vikings

Tampa Bay Buccaneers at Carolina Panthers

Jacksonville Jaguars at New York Jets

Detroit Lions and Atlanta Falcons

Los Angeles Chargers at Houston Texans

Baltimore Ravens at Cincinnati Bengals

Chicago Bears at Seattle Seahawks

Pittsburgh Steelers at Kansas City Chiefs

Washington Football Team at Dallas Cowboys

Miami Dolphins at New Orleans Saints